Based on the studies by Dimitrios K. Raios and Martin Sicherl, this article reviews some of the main hypotheses proposed concerning the genesis of Philostratus’s collected letters before and during the process of their inclusion in the Aldine edition by the scholar Marcus Musurus. This very preliminary analysis of the relationships between the codices most directly involved in the production of the Aldine edition suggests some initial conclusions which, although not definitive, call these hypotheses into question.