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Principles of Ethical Research Owen Price and Lauren Walker Chapter overview By definition, research seeks to explore something that is unknown. This uncertainty means there is always the possibility of harm arising from research. There are many examples in both near and distant history of serious harm to participants as a consequence of research, including permanent disability and death. This is why it is of great importance that research projects are informed by sound ethics, properly planned, approved by an independent ethical board and rigorously monitored

in A research handbook for patient and public involvement researchers