This study brings emergent methodologies of literary geography to bear upon the unique contents—or more to the point, the moving, artful, frequently audacious contents—of a codex known as London, British Library MS Harley 2253. The Harley manuscript was produced in provincial Herefordshire, in England’s Welsh Marches, by a scribe whose literary generation was wiped out in the Black Death of 1348–1351. It contains a diverse set of writings: love-lyrics and devotional texts, political songs and fabliaux, saints’ lives, courtesy literature, bible narratives, travelogues, and more. These works alternate between languages (Middle English, Anglo-Norman, and Latin), but have been placed in mutually illuminating conversation. Following an Introduction that explores how this fragmentary miscellany keeps being sutured into ‘whole’-ness by commentary upon it, individual chapters examine different genres, topics, and social groupings. Readers from literary history, medieval studies, cultural geography, gender studies, Jewish studies, book history, and more, will profit from the encounter. Harley 2253 is famous as medieval books go, thanks to its celebrated roster of lyrics, fabliaux, and political songs, and owing to the scarcity of material extant from this ‘in-between’ period in insular literary history. England’s post-Conquest/pre-plague era remains dimly known. Despite such potential, there has never been a monograph published on Harley 2253. Harley Manuscript Geographies orients readers to this compelling material by describing the phenomenon of the medieval miscellany in textual and codicological terms. But another task it performs is to lay out grounds for approaching this compilation via the interpretive lens that cultural geography provides.